Abstract #0296
A one-stop-shop for hemodynamic imaging in Moyamoya disease
Peiying Liu 1 , Babu G Welch 2 , Darlene King 2 , Yang Li 1 , Marco Pinho 1,3 , and Hanzhang Lu 1
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
United States,
2
Neurological
Surgery Clinic, University of Texas Southwestern Medical
Center, Dallas, Texas, United States,
3
Department
of Radiology, University of Texas Southwestern Medical
Center, Texas, United States
Brain stenotic diseases such as moyamoya disease (MMD)
are characterized by diminished cerebrovascular reserve.
In this work, we proposed a one-stop-shop method for
hemodynamic imaging in cerebrovascular diseases, in
which venous cerebral blood volume (vCBV) and
cerebrovascular reactivity (CVR), as well as a response
time (RT) map reflecting kinetic properties are obtained
in a single scan of about 9 minutes without need for
radiation exposure of administration of exogenous
contrast agents. We showed that MMD patients have
diminished vasodilatory function while their baseline
vCBV was intact. This method may be a practical and
valuable method in cerebrovascular diseases.
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