Abstract #0222
In vivo and ex vivo diffusion tensor imaging parameters follow Collagen 1 fiber distribution in breast cancer xenograft model
Samata M Kakkad 1,2 , Jiangyang Zhang 1 , Alireza Akhbardeh 1 , Desmond Jacob 1 , Meiyappan Solaiyappan 1 , Michael A Jacobs 1 , Venu Raman 1 , Dieter Leibfritz 2 , Kristine Glunde 1 , and Zaver M Bhujwalla 1
1
Radiology, The Johns Hopkins University
School of Medicine, Baltimore, MD, United States,
2
University
of Bremen, Bremen, Germany
Col1 fibers play an important role in molecular
transport and cancer cell dissemination. We investigated
the influence of Col1 fibers on water diffusion, using a
breast cancer xenograft fluorescing under hypoxia. We
observed that hypoxic regions contained significantly
fewer Col1 fibers, and were characterized by a lower ADC
and FA compared to normoxic tumor regions. In vivo DTI
distribution patterns were spatially similar to those
observed ex vivo, suggesting that noninvasive DTI
parameters provided noninvasive indices of Col1 fiber
distribution in tumors.
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