Abstract #0221
Diffusion Weighted MRI for Early Detection and Progression Monitoring of Prostate Cancer in a Transgenic Mouse Model
Deborah K. Hill 1,2 , Eugene Kim 1,2 , Jose R. Teruel 1,2 , Siver A. Moestue 1,2 , and Tone F. Bathen 1
1
Department of Circulation and Medical
Imaging, Norwegian University of Science and Technology,
Trondheim, Sr Trndelag, Norway,
2
St.
Olavs University Hospital, Trondheim, Sr Trndelag,
Norway
The effectiveness of DW-MRI for both detecting early
onset of prostate cancer (PCa) and for characterising
disease progression was investigated for the transgenic
adenocarcinoma of the mouse prostate (TRAMP) model in
mice. DWI facilitated early detection of tumour onset in
TRAMP mice prostates before lesions were seen on
high-resolution T2W images. Histograms are sensitive to
distinguishing cancer from prostate tissue, where
bimodal distributions were clearly visible in the case
of cancer onset. Median ADC values of prostate regions
were in agreement with literature values for different
stages of PCa progression, thus providing a non-invasive
means to assess cancer aggressiveness.
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