Abstract #0092
Hyperpolarized 13 C-alpha-ketobutyrate, a pyruvate analog
Cornelius von Morze 1 , Robert A Bok 1 , Michael A Ohliger 1 , Daniel B Vigneron 1 , and John Kurhanewicz 1
1
Department of Radiology & Biomedical
Imaging, UCSF, San Francisco, California, United States
In this work we demonstrate hyperpolarization and rapid
in vivo enzymatic conversion of an endogenous structural
analog of
13
C-pyruvate,
13
C-alpha-ketobutyrate,
via lactate dehydrogenase (LDH). Based on prior non-MR
work and our own initial results, this hyperpolarized
probe may exhibit useful selectivity for LDHB-expressed
isoforms of LDH, such as heart or kidney LDH.
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