Abstract #0060
Accelerated Echo Planer J-resolved spectroscopic imaging of Insular Cortex and Putamen in Obstructive sleep apnea
Manoj Kumar Sarma 1 , Paul Michael Macey 2 , Rajakumar Nagarajan 1 , Ravi Aysola 3 , and M.Albert Thomas 1
1
Radiological Sciences, UCLA School of
Medicine, Los angeles, CA, United States,
2
School
of Nursing, UCLA School of Medicine, Los angeles, CA,
United States,
3
Division
of Pulmonary and Critical Care Medicine, UCLA School of
Medicine, Los angeles, CA, United States
Patients with obstructive sleep apnea syndrome (OSAS)
shows significant autonomic and neuropsychologic
deficits, which may derive from damage to insular
cortices and putamen, two key limbic structures that
serve such functions. Here we examined neurochemical
changes in the insular cortices and putamen of OSAS
patients to provide indications of the nature of tissue
changes using compressed sensing based 4D echo-planar
J-resolved spectroscopic imaging. tCho/Cr ratio was
reduced significantly in right insular cortex, and
Glx/Cr, Glu/Cr ratios increased in the left insular
cortex and right putamen respectively. Significantly
increased GABA/Cr was found in right insular cortex with
both insular cortex and putamen showing decreased tNAA,
NAA and increased mI bilaterally. These findings will
provide insight into structural brain changes in OSAS,
and suggest possible treatment options to address common
central nervous system symptoms in the sleep disorder.
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