Abstract #4916
An untargeted metabolomics approach to ultra high field MRS in spinocerebellar ataxia
Uzay Emrah Emir 1,2 , Margarida Juli-Sap 3 , Peter Jezzard 1 , Diane Hutter 2 , Khalaf O Bushara 2 , and Gulin Oz 2
1
FMRIB Centre, University of Oxford, Oxford,
United Kingdom,
2
University
of Minnesota, Minneapolis, Minnesota, United States,
3
Centro
de Investigacin Biomdica en Red en Bioingeniera,
Biomateriales y Nanomedicina (CIBER-BBN), Universitat
Autnoma de Barcelona, Cerdanyola del Valls, Spain
A metabolomics approach to analyzing in vivo MRS data
might benefit substantially from ultra high field (UHF)
due to the improved sensitivity and resolution. In this
study, we explored the potential of a metabolomics
approach to MRS by comparing patients with
spinocerebellar ataxia type 1 (SCA1) to healthy controls
both at 3T and 7T. Due to high spectral quality at both
fields, distinct clustering with a complete separation
between SCA1 and controls was achieved. The improved
sensitivity and resolution at 7T enabled identification
of three distinct spectral features whereas only 2
distinct features were identified at 3T.
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