Abstract #4751
Characterization of a 60-minute MCAO using immunohistochemical evaluation in conjunction with MRI
Lora Talley Watts 1 , Qiang Shen 1 , and Timothy Duong 1
1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
TX, United States
This study examined the expression of an early and late
marker of the apoptotic cascade associated with
perfusion and diffusion abnormality at 2 and 24 hours
following a 60 minute MCAO in rats. Quantitative
correlations of apoptotic expression were made with ADC
and CBF measures. We found a strong correlation of ADC
and CBF values with molecular markers of apoptosis and
cell death. The finding provide molecular underpinnings
of quantitative prediction of ischemic fate and
functional reorganization based on acute MRI data.
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