Abstract #4750
Translational implementation of non-invasive Magnetic Resonance brain oxygen mapping in acute (72 hours) ischemic stroke patients
Florence Colliez 1 , Julie Magat 1 , Marta M Safronova 2 , Bndicte F Jordan 1 , Bernard Gallez 1 , and Thierry Duprez 3
1
Louvain Drug Research Institute, Biomedical
Magnetic Resonance Research Group, University of
Louvain, Brussels, Belgium,
2
Service
de Radiologie, Cliniques universitaires Saint-Luc,
Brussels, Belgium,
3
Department
of Radiology and Medical Imaging, Cliniques
universitaires Saint-Luc, Brussels, Belgium
Mapping brain oxygenation is a key-challenge in the
clinical work-up of many cerebral disorders.
Measurements of proton T1 relaxation induced by
paramagnetic molecular oxygen have previously
demonstrated capability to monitor changes in tissue
oxygenation. The MOBILE (Mapping of Oxygen by Imaging
Lipid relaxation Enhancement) sequence increases the
sensitivity of this measurement by selectively
calculating the spin-lattice (T1) relaxation of lipids
after suppressing water signal. We hereby investigated
in a translational proof of concept way whether MOBILE
enabled detection of brain oxygen deprivation in the
clinical setting of ischemic acute ischemic (72 hours)
stroke patients.
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