Abstract #4502
Diffusion Tensor Imaging of Rat Brains Following Long-term Passive Acoustic Exposure at Moderate Sound Pressure Level
Condon Lau 1 , Sherwin Abdoli 2 , Leon C Ho 3,4 , Jevin W Zhang 3,4 , and Ed X Wu 3,4
1
Division of Biomedical Engineering, HKUST,
Kowloon, Hong Kong,
2
Keck
School of Medicine, University of Southern California,
CA, United States,
3
Department of Electrical
and Electronic Engineering, The University of Hong Kong,
Hong Kong, Hong Kong,
4
Laboratory
of Biomedical Imaging and Signal Processing, The
University of Hong Kong, Hong Kong, Hong Kong
Diffusion tensor imaging was used to observe changes in
the brain structure of rats (n=16) following two months
of continuous and passive acoustic exposure at moderate
sound pressure level. Voxel-based statistics (VBS)
revealed greater fractional anisotropy of the pyramidal
tract, tectospinal tract, intertwined trigeminothalamic
tract and medial lemniscus of the exposed rats than of
the control rats. ROIs were drawn for the structures
indicated and applied to the fractional anisotropy and
mean diffusivity maps. ROI analysis confirmed that in
the structures indicated by VBS, fractional anisotropy
was higher and mean diffusivity was lower in exposed
rats than in normal rats.
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