Abstract #4029
35Cl and 23Na MRI of 9L rat glioma at 21.1 T
Victor D. Schepkin 1 , Malathy Elumalai 2 , Jason Kitchen 3 , Chunqi Qian 4 , Peter Gor'kov 1 , and William Brey 1
1
CIMAR, NHMFL/FSU, Tallahassee, FL, United
States,
2
AMRIS,
NHMFL/UF, Gainesville, FL, United States,
3
CIMAR,
NHMFL/FSU, Tallahassee, Florida, United States,
4
NINDS/NIH,
Bethesda, MD, United States
Chloride is a unique window for investigating brain
function and cancer development. The in vivo challenges
of low sensitivity, short T2 relaxation time and the
small size of the acquisition matrix were evaluated
here. The experiments in normal rat brain and glioma
revealed: chloride in vivo is as visible as the sodium
MR signal. However, the bi-exponential FID and limited
sampling size dramatically affect the quantification of
images and needs to be corrected according to the
developed Matlab model. The finding of increased
chloride concentration in glioma correlates with the
hypothesis stating a critical role of chloride for tumor
progression.
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