Abstract #3529
Quantification of lung microstructure in asthma using a 3 He fractional diffusion approach
Juan Parra-Robles 1 , Helen Marshall 1 , Ruth A Hartley 2 , Christopher E Brightling 2 , and Jim M Wild 1
1
Unit of Academic Radiology, University of
Sheffield, Sheffield, United Kingdom,
2
Institute
for Lung Health, University of Leicester, Leicester,
United Kingdom
In this work, a new approach based on a fractional
diffusion model is developed to allow for in-vivo
estimation of the distributions of the microscopic
length scales of acinar airways from
3
He
diffusion MRI data. This new technique is used to assess
the acinar microstructure in asthma patients and the
results are compared with CT densitometry and
macroscopic
3
He
ventilation distributions.
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