Abstract #3528
Gray and white matter abnormalities in patients with nocturnal frontal lobe epilepsy
Laura Ludovica Gramegna 1 , David Neil Manners 1 , Claudia Testa 1 , Claudio Bianchini 1 , Ilaria Naldi 2 , Lorenzo Ferri 2 , Francesca Bisulli 2,3 , Paolo Tinuper 2,3 , Raffaele Lodi 1 , and Caterina Tonon 1
1
Functional MR Unit, Department of Biomedical
and NeuroMotor Sciences (DiBiNeM), University of
Bologna, Bologna, Italy,
2
Department
of Biomedical and NeuroMotor Sciences (DiBiNeM),
University of Bologna, Bologna, Italy,
3
IRCCS
Institute of Neurological Science of Bologna, Bologna,
Italy
Nocturnal frontal lobe epilepsy (NFLE) includes
paroxysmal episodes appearing almost exclusively during
sleep. The pathophysiology of NFLE is not yet fully
understood and distinguishing NFLE seizures from
paroxysmal non-epileptic sleep disorders is difficult.
We used VBM and TBSS to evaluate brain tissue density
and white matter microstructure in 20 NFLE patients.
Compared to healthy controls NFLE patients showed
widespread white matter microstructural alterations.
Right frontal-orbital gray matter density was reduced in
more severely affected patients. Our findings may help
to better understand the pathophysiology of NFLE and to
differentiate NFLE from other non-epileptic motor
phenomena arising from sleep.
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