Abstract #3102
Reproducibility of M, CMRO2 and OEF measurements using QUO2 MRI and dual-echo pCASL
Isabelle Lajoie 1 , Felipe B Tancredi 1 , Danny J Wang 2 , and Richard D Hoge 1
1
Centre de recherche de l'IUGM, Montreal,
Quebec, Canada,
2
Neurology,
University of California, Los Angeles, CA, United States
We describe here an optimized protocol for the
acquisition and processing of MRI data for the
quantification of oxidative metabolism (CMRO2) using the
QUantitativeO2 (QUO2) method with fixed concentrations
of respirator gases and a DE-pCASL sequence. We assessed
the reproducibility of the method and obtained
respective inter-session coefficients of variation (CV)
of 10%, 15%, and 17% for M (extrapolated maximum BOLD
signal), OEF0 (Oxygen Extraction Fraction) and CMRO20.
In future work, we will extend the protocol to MRI
scanners from multiple scanner vendors and verify that
equivalent results can be obtained at different scanning
sites.
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