Abstract #2918
Time Course Study on Glucose Metabolism in Mice by Spectroscopic Imaging with 2D Heteronuclear Multiple Quantum Coherence
Hirohiko Imai 1 , Yuki Takayama 1 , and Tetsuya Matsuda 1
1
Department of Systems Science, Graduate
School of Informatics, Kyoto University, Sakyo-ku,
Kyoto, Japan
We demonstrate the feasibility of a
1
H-
13
C
heteronuclear multiple quantum coherence (HMQC) MRSI for
imaging metabolite dynamics. The
1
H-
13
C
HMQC MRSI was performed for the whole-body acquisition
of four tumor-bearing mice after sacrifice at 5min,
8min, 30min, and 20hr post injection of [U-
13
C]glucose.
Form acquired 4D data set (two spectral and two spatial
dimensions), the signal intensity ratio of lactate (Lac)
to glucose (Glc) was mapped. When focusing on the tumor,
the Lac/Glc value increased with time, reflecting the
accumulation of Lac as a metabolic end product from Glc
in the tumor.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
