Abstract #2842
MRI of myocardial infarction with Vasovist: A potential marker for permeability in MI
Andrea Protti 1 , Xuebin Dong 1 , Silvia Lorrio 2 , Alkystis Phinikaridou 2 , Begona Lavin 2 , Ajay Shah 1 , and Rene Botnar 2
1
Kings College London British Heart
Foundation Centre of Excellence, London, UK, United
Kingdom,
2
King's
College London, London, UK, United Kingdom
Introduction. The pathophysiological and molecular
mechanisms of cardiac remodeling after the onset of MI
have been widely studied with histochemistry techniques
[1] and imaging techniques such as echocardiography [2]
and MRI. Such studies suggest a degradation of the
matrix leading to creation of a collagen-based scar with
some elastin content. Elastin is important because it
may provide a degree of elasticity to the infarcted
tissue thus decreasing the risk of myocardial rupture.
In this study, we investigated the elastin content of
the infarcted myocardium in a mouse model using MRI
after injection of the ESMA contrast agent. Areas of
uptake and relaxation values over a longitudinal study
were estimated.
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