Abstract #2841
Bovine Serum Albumin (BSA) as Ultrasmall Nanoparticles Carrier: Application to MRI Contrast Agents
Md Wasi Ahmad 1 , Wenlong Xu 1 , Badrul Alam Bony 1 , Tirusew Tegafaw Mengesha 1 , Cho Rong Kim 1 , Sung June Kim 1 , and Gang Ho Lee 1
1
Chemistry, Kyungpook National University,
Daegu, Korea
Biological molecules are suitable carriers of ultrasmall
nanoparticles for biomedical applications. In this
study, we investigate: (1) BSA is a good nanoparticles
carrier (2) MR relaxivity measurements revealed that BSA-PEG
diacid-ultrasmall Gadolinium oxide nanoparticles (BSA-PEGD-GNPs)
had larger r1 and r2 values than those of the molecular
Gd-chelates (3) The 3 tesla T2 MR images after injecting
the aqueous sample solution of BSA-PEGD-GNPs into the
mouse tail vein showed clear negative contrast
enhancements, confirming that the sample solution
functioned as a T2 MRI contrast agent
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