Abstract #2146
T 2 * from fat-water MRI is sensitive to local adipose tissue inflammatory changes in a diet-induced obesity mouse model at 15T
Henry H. Ong 1,2 , Corey D. Webb 3 , Marnie L. Gruen 3 , Alyssa H. Hasty 3 , John C. Gore 1,2 , and E. Brian Welch 1,2
1
Vanderbilt University Institute of Imaging
Sciences, Nashville, TN, United States,
2
Radiology
and Radiological Sciences, Vanderbilt University,
Nashville, TN, United States,
3
Molecular
Physiology and Biophysics, Vanderbilt University School
of Medicine, Nashville, TN, United States
In obesity, fat-water MRI (FWMRI) methods provide
valuable information on adipose tissue (AT)
distribution. AT is known to undergo complex metabolic
and endocrine changes in association with chronic
inflammation. We investigated the potential for
quantitative FWMRI to be sensitive to AT inflammatory
changes in an established diet-induced obesity mouse
model. We examined T
2
*
estimates
from the fat-water separation algorithm and observed an
increasing shift toward higher T
2
*
values
in perirenal AT with increasing obesity as compared with
normal weight mice. Quantitative FWMRI T
2
*
measurement
shows potential for longitudinal non-invasive assessment
of AT dysfunction in obesity.
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