Abstract #2071
Analysis of Inhomogeneous Magnetization Transfer Applied In Patients with Multiple Sclerosis
Gopal Varma 1 , Mohit Neema 2 , Fotini S Papadopoulou 1 , Shahamat Tauhid 2 , Rohit Bakshi 2 , and David C Alsop 1
1
Radiology, Division of MR Research, Beth
Israel Deaconess Medical Center, Harvard Medical School,
Boston, MA, United States,
2
Department
of Neurology, Brigham and Women's Hospital, Harvard
Medical School, Boston, MA, United States
The apparent specificity of inhomogeneous magnetization
transfer (IHMT) to myelinated tissue lends itself to
study in pathologies related to myelin loss. A
preliminary results from IHMT applied in patients with
multiple sclerosis (MS) are reported. A statistically
significant difference is found from the IHMT ratio in
comparison with a group of healthy volunteers for a
posterior region of interest. The difference within this
region is less significant in analysis of the more
commonly used MT ratio. IHMT might therefore provide a
potential improvement over MT in analysis of MS and
other myelin related diseases.
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