Abstract #2070
Longitudinal mixed-effect model analysis of the association between global and tissue specific brain atrophy and lesion accumulation in patients with CIS
Mihael Varosanec 1 , Dana Horakova 2 , Jesper Hagemeier 1 , Niels Bergsland 1 , Michaela Tyblova 2 , Zdenek Seidl 3 , Manuela Vaneckova 3 , Jan Krasensky 3 , Michael G. Dwyer 1 , Eva Havrdova 2 , and Robert Zivadinov 1
1
Buffalo Neuroimaging Analysis Center,
Department of Neurology, University at Buffalo SUNY,
Buffalo, NY, United States,
2
Department
of Neurology and Center of Clinical Neuroscience,
Charles University in Prague, Prague, Czech Republic,
3
Department
of Radiology, First Faculty of Medicine and General
University Hospital, Charles University in Prague,
Prague, Czech Republic
We investigated accumulation of new brain lesion, lesion
volume, and contrast enhancing lesions with respect to
the atrophy of gross brain structures in patients with
clinically isolated syndrome. Longitudinal linear and
quadratic mixed effect model analyses were performed for
each time point and in dual directions. The more robust
inverse mixed-effect model results suggest that the
level of brain atrophy can explain T2 lesion
accumulation better than the T2 lesion accumulation can
explain accumulation of brain atrophy. These results
suggests that close monitoring of brain volume changes
may be relevant for identifying patients at risk for MS
conversion.
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