Abstract #2015
Simulation of Diffusion Changes in Different Pathologies After Traumatic Brain Injury
Mu Lin 1 , Hongjian He 1 , and Jianhui Zhong 1
1
Center for Brain Imaging Science and
Technology, Zhejiang University, Hangzhou, Zhejiang,
China
In order to investigate different pathological changes
influences on DTI parameters such as axial diffusivity,
radial diffusivity, mean diffusivity and fractional
anisotropy and to explain the contradictious clinical
observations, a Monte Carlo simulation study was
conducted. The preliminary results showed that, in acute
stage, axonal injury and cytotoxic edema were the
primary factors determining DTI parameter changes, and
they could literally lead to opposite observations. In
subacute stage, demyelination and vasogenic edema were
the predominant factors, which affected DTI parameters
in a similar way. Axial and radial diffusivity were
sensitive to axonal injury and demyelination, but they
were easily disrupted by edema., but they were easily
disrupted by edema.
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