Abstract #1497
Apparent Exchange Rate (AXR) Mapping Using Diffusion MRI: an in vitro and in vivo Feasibility Study on Breast Cancer
Samo Lasic 1 , Savannah C. Partridge 2 , Cheng-Liang Liu 2 , Stina Oredsson 3 , Lao Saal 4 , Daniel Topgaard 5 , Markus Nilsson 6 , and Karin Bryskhe 1
1
CR Development AB, Lund, Sweden,
2
Dept.
of Radiology, University of Washington, Seattle Cancer
Care Alliance, Seattle, United States,
3
Department
of Biology, Lund University, Lund, Sweden,
4
Department
of Oncology, Lund University Hospital, Lund, Sweden,
5
Center
for Chemistry and Chemical Engineering, Lund University,
Lund, Sweden,
6
Lund
University Bioimaging Center, Lund University, Lund,
Sweden
A feasibility study of filter exchange imaging (FEXI)
for detection of apparent exchange rate (AXR) was
performed on breast cancer cell lines and on a breast
tumour patient in vivo. Results suggest that different
breast cancer types could be distinguished with FEXI
based on their AXR values. The AXR could be determined
for the tumour ROI, while in normal tissue the AXR was
outside the experimental range. Low SNR did not allow
voxel based data analysis. Further optimization of FEXI
will be required before FEXI can be evaluated in a
larger group of breast cancer patients.
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