Abstract #1496
Transverse Relaxation Amplified by Chemical Exchange (TRACE): A New Method for Mapping Molecular Integrity of Cartilage
Anup Singh 1 , Ravi Prakash Nanga 1 , Mohammad Haris 1,2 , Kejia Cai 1,3 , Felik Kogan 1 , Hari Hariharan 1 , and Ravinder Reddy 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
2
Research
Branch, Sidra Medical and Research Center, Doha, Qatar,
3
Radiology,
University of Illinois at Chicago, Chicago, IL, United
States
Objective of current study was to develop a new method
for mapping molecular integrity of cartilage based upon
Transverse Relaxation Amplified by Chemical Exchange
(TRACE). This simple and time efficient method provides
a quantitative index of macromolecular content of
cartilage and is less sensitive to fluid changes
associated with pathological conditions of the tissue.
The method was tested in chondroitin sulfate (CS)
phantoms with different concentrations and pH as well as
on human knee cartilage at 3T and 7T whole body MR
scanners.
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