Abstract #1247
T1 imaging demonstrates inflammatory changes in disc endplates that were not visible in T1 or T2 weighted images
L.Tugan Muftuler 1 , Dhiraj Baruah 2 , and Andrew Klein 2
1
Department of Neurosurgery and Center for
Imaging Research, Medical College of Wisconsin,
Milwaukee, WI, United States,
2
Department
of Radiology, Medical college of Wisconsin, WI, United
States
In some patients with low back pain, degenerative marrow
changes are observed in the endplates around the
degenerating intervertebral discs. These changes are
classified based on the appearance of vertebrae in T1
and T2 weighted MRI. Type-1 changes usually involve
early inflammatory changes and believed to play a role
in pain generation. Type-2 changes generally involves
conversion to fatty marrow. Although this classification
is widely accepted, those images may not be sufficiently
sensitive to early changes. Increases in T1
relaxation
rate were reported in regions of inflammation in
animals. Therefore, we tested the efficacy of T1
imaging
in endplate degeneration.
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