Abstract #1236
31P Wideband Inversion Transfer for Measuring ATP Synthesis Rates in Human Skeletal Muscle
Jimin Ren 1 , Baolian Yang 2 , A. Dean Sherry 1,3 , and Craig R. Malloy 1,4
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
United States,
2
Philips
Healthcare, Ohio, United States,
3
University
of Texas at Dallas, Richardson, Texas, United States,
4
VA
North Texas Health Care System, Texas, United States
There has been a long-standing interest in measuring ATP
synthesis rates in vivo. Conventional 31P saturation
transfer requires prolonged saturation of gamaATP while
inversion transfer by selective-inversion of gamaATP is
less efficient, all due to rapid leaking of
magnetization to other spins in the exchange network,
especially phosphocreatine(PCr). Wideband inversion
overcomes this problem by simultaneously inverting both
PCr and ATP spins, allowing efficient transfer of
magnetization to Pi. The advantage of wideband inversion
is more evident at higher fields due to the increased
PCr T1 value. The single 31P inversion pulse necessary
for this technique is easy to implement.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
