Abstract #1235
Characterization of Metabolic Response to Ischemia in Skeletal Muscle of Non-obese Early Stage Type 2 Diabetic Rats by in vivo 31P MRS and BOLD MRI
Yuchi Liu 1 , Xunbai Mei 1 , Nicola Lai 1,2 , and Xin Yu 1,3
1
Biomedical Engineering, Case Western Reserve
University, Cleveland, Ohio, United States,
2
Pediatrics,
Case Western Reserve University, Ohio, United States,
3
Radiology,
Case Western Reserve University, Ohio, United States
This study investigated the metabolic response to
ischemia in skeletal muscle of non-obese early stage
type 2 diabetic rats. 31P spectra and BOLD images were
acquired in an interleaved fashion at baseline, during
25-min ischemia, and 20-min reperfusion. The diabetic
group showed less reduction in phosphocreatine (PCr) and
less increase in inorganic phosphate (Pi) during
ischemia. Diabetic rats also showed greater signal
reduction in BOLD images during ischemia, possibly due
to increased oxygen extraction. Both diabetic and
control groups have similar PCr recovery kinetics during
reperfusion. These data suggest that mitochondrial
function may remain normal in early stage type 2
diabetes.
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