Abstract #0532
The Potential Advantage of High Resolution In Vivo 31P-MRS in the Assessment of Nonalcoholic Fatty Liver Disease
Yunjung Lee 1 and Hyeonjin Kim 1,2
1
Radiology, Seoul National University
Hospital, Seoul, Korea,
2
Biomedical
Sciences, Seoul National University, Seoul, Korea
The advantage of high resolution in-vivo 31P-MRS in
assessing nonalcoholic fatty liver disease (NAFLD) was
investigated at 9.4T in CCl4-treated rats. In all
spectra phosphomonoester (PME) and phosphodiester (PDE)
were well resolved into phosphoethanolamine (PE) and
phosphocholine (PC), and into
glycerophosphorylethanolamine (GPE) and
glycerophosphorylcholine (GPC), respectively. Those MRS
measures quantifiable only in highly resolved spectra
had higher correlations with histology than those
conventional MRS measures. In multivariate analyses the
statistical model allowed the classification and
prediction of the animals according to disease severity
with 70-80% accuracy. High resolution in-vivo 31P-MRS
may further extend the applicability of 31P-MRS in
assessing NAFLD.
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