Abstract #0531

Validation of a multiple-echo DSC-MRI approach with T1 and T2* leakage correction for brain tumor perfusion imaging

Ashley M Stokes ^1,2 , Natenael Semmineh ^1,3 , and C. Chad Quarles ^1,2

¹ Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ² Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, ³ Physics and Astronomy, Vanderbilt University, Nashville, TN, United States

Contrast agent (CA) leakage in tumors can lead to incorrect hemodynamic measures in DSC-MRI; therefore, DSC Capital Greek Delta

R ₂ ^* signals must be leakage corrected to provide accurate CBF and CBV. We propose removing T ₂ ^* leakage effects in T ₁ -insensitive dual-echo Capital Greek Delta

R ₂ ^* by estimating the extravascular CA relaxivity using the transverse relaxivity at tracer equilibrium (TRATE). In rat glioma, we compared the uncorrected CBV and CBF to corrected values using the Weisskoff and TRATE corrections; these were further compared to MION reference values. The Weisskoff and TRATE corrections led to CBVs that were closer to the MION values, but both underestimated CBF.

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