Abstract #0108
Coronary Wall Thickening in HIV-infected Youth in Association with Antiviral Therapy using Time-Resolved DIR MRI (TRAPD)
Khaled Z. Abd-Elmoniem 1 , Aylin Unsal 1 , Julia B. Purdy 1 , Rohan Hazra 1 , Colleen Hadigan 1 , and Ahmed M. Gharib 1
1
National Institutes of Health, Bethesda, MD,
United States
HIV early in life may result in premature vasculopathy
and cardiovascular disease. To this effect 35 young
adults infected with HIV early in life and 11 health
controls were included in this study. All subjects
underwent coronary vessel wall imaging using TRAPD
method at 3T and coronary MDCT. HIV infected subjects
had significantly thicker vessel wall than controls as
measured by MR without accompanying difference in plaque
burden as measured by CT. The former was related to
years of antiviral therapy exposure. This MR method
provides evidence of vascular injury in antiviral
therapy exposure and not associated with coronary
atherosclerosis.
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