Abstract #0077
Concurrent ASL and BOLD FMRI of Working Memory in Typically Developing Population
Lirong Yan 1 , Emily Kilroy 2 , Mayank Jog 1 , and Danny JJ Wang 1
1
University of California Los Angeles, Los
Angeles, CA, United States,
2
University
of Southern California, Los Angeles, CA, United States
Due to the lack of assays of baseline function and
absolute quantification of task-induced effect size, it
is hard to interpret developmental BOLD fMRI findings.
In this study, a concurrent ASL/BOLD fMRI paradigm of
working memory tasks was employed to investigate the
relationship between CBF and BOLD responses in 57
children and adolescents aged 7 to 17. Our results
showed that while the percentage of BOLD response
increases with age, both baseline CBF and absolute
task-induced CBF decrease with age, suggesting more
efficient use of oxygen of the brain during development.
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