Abstract #0076
Investigation of Longitudinal Neurodevelopment using Quantitative MRI
Douglas C Dean 1 , Jonathan O'Muircheartaigh 1,2 , Holly Dirks 1 , Nicole Waskiewicz 1 , Lindsay Walker 1 , and Sean C.L. Deoni 1
1
School of Engineering, Brown University,
Providence, RI, United States,
2
Neuroimaging,
King's College London, Institute of Psychiatry, United
Kingdom
Quantitative MRI affords a unique opportunity to map the
dynamic patterns of neurodevelopment and provide insight
into the relationships between brain maturation and
emerging cognition. Longitudinal developmental
trajectories of quantitative T1, T2, and the myelin
water fraction (VFM) from 103 typically developing
children are presented and characterized using
non-linear mixed effects modeling. We furthermore
examine the relationships between changes in these
quantitative parameters and measures of cognition. Our
results reflect the coincident development of myelinated
white matter and cognitive ability; providing an
important step for understanding the typical patterns of
normative white matter maturation and its relationship
to emerging function.
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