Abstract #4511

Investigation of Cardiac Malate-Aspartate Shuttle at High Workload Using Hyperpolarized [1,2-13C2]pyruvate

Albert P. Chen¹, Angus Z. Lau²,³, Yi-ping Gu², Marie A. Schroeder⁴, Jennifer Barry⁵, Charles H. Cunningham²,³

¹GE Healthcare, Toronto, ON, Canada; ²Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; ³Dept. of Medical Biophysics , University of Toronto, Toronto, ON, Canada; ⁴Dept. of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom; ⁵Imaging Research, Sunnybrook Research Institute, Toronto, ON, Canada

This study demonstrated that changes in α-ketoglutarate derived glutamate could be monitored non-invasively and independently from PDC flux using hyperpolarized [1,2-13C2]pyruvate at different cardiac workloads. A reduction in the glutamate to bicarbonate ratio may indicate a limited transport of reducing equivalent across mitochondria membrane via malate-aspartate shuttle at high cardiac workload.