Abstract #4221

In Vivo Detection of ParaCEST Contrast Agents at 9.4T

Nevin McVicar¹, Alex Li², Mojmir Suchy,²³, Robert H.E Hudson³, Robert Bartha,¹²

¹Medical Biophysics, University of Western Ontario, London, ON, Canada; ²Imaging Research Group, Robarts Research Insitute, London, ON, Canada; ³Chemistry, University of Western Ontario, London, ON, Canada

In vitro properties are characterized for four paraCEST contrast agents. Each paraCEST agent was then individually injected directly into a mouse leg prior to immediate acquisition of CEST spectra. All four agents were detected in vivo. Using the properties measured in vitro along with the paraCEST contrast measured in vivo, it is concluded that in vivo performance can be predicted based on in vitro characterization of the MR properties of each agent.