Abstract #4053

Estimation of Gastric Secretions After a Nutrient Test Meal Using T1 Mapping MRI.

Caroline L. Hoad¹, Helen Parker², Emily Tucker², Carolyn Costigan¹, Eleanor F. Cox¹, Luca Marciani², Mark R. Fox², Penelope A. Gowland¹

¹Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; ²Biomedical Research Unit in Gastrointestinal and Liver Diseases, Nottingham University Hospital NHS Trust and University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

This study describes an MRI technique to estimate gastric secretions after ingestion of a nutrient test meal. Gastric secretions were estimated from T₁ maps generated from IR-EPI data in the body of the stomach and in-vitro calibration data which diluted the Gd-DOTA doped test meal with simulated gastric secretions. Good agreement was found between estimated gastric secretion volume and secretion layer and _&[kappa] a parameter used in a model of gastric emptying which reflects the early changes in volume due to secretion and emptying. A lower _&[kappa] was seen in functional dyspepsia patients with no change in secretion volume observed.