Sarah C. Wayte1,
Narendra L. Reddy2, Terence A. Jones2, Oludolapo
Adesanya3, Yen C. Yoe4, Harpal S. Randeva2,
Sudhesh Kumar2, Charles E. Hutchinson2, 3,
Thomas M. Barber2
1Department
of Medical Physics, University Hospitals Coventry and Warwickshire, Coventry,
West Midlands, United Kingdom; 2Warwick Medical School, University
Hospitals Coventry and Warwickshire, Coventry, West Midlands, United Kingdom;
3Department of Radiology, University Hospitals Coventry and
Warwickshire, Coventry, West Midlands, United Kingdom; 4Department
of Histopathology, University Hospitals Coventry and Warwickshire, Coventry,
West Midlands, United Kingdom
Potentially, Dixon imaging offers a safe reliable method for serial monitoring of brown adipose tissue (BAT) volume. We present the first histologically confirmed identification of BAT in an adult human using Dixon imaging. The patient was imaged using 18FDG PET-CT CT and IDEAL MR. ROIs were identified in areas of high uptake on PET-CT and registered onto the MR images. A significant difference (p<0.0001) was found between the MR signal within these ROIs and neighbouring white adipose tissue (WAT) regions. The overall BAT:WAT signal ratio was (0.890.12). Histology confirmed the presence of BAT in a low signal region identified on MR.