Cristina Cudalbu1,
Valrie A. McLin2, Olivier Braissant3, Rolf Gruetter4,
5
1Laboratory
for Functional and Metabolic Imaging (LIFMET), Center for Biomedical Imaging (CIBM),
Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Vaud, Switzerland;
2Dpartement de l'Enfant et de l'Adolescent, Unit de
Gastroentrologie, Hpatologie et Nutrition, Hpitaux Universitaires de
Genve (HUG), Geneva, Switzerland; 3Service of Biomedicine,
Lausanne University Hospital, Lausanne, Vaud, Switzerland; 4Laboratory
for Functional and Metabolic Imaging (LIFMET), Center for Biomedical Imaging
(CIBM), cole Polytechnique Fdrale de Lausanne, Lausanne, Vaud,
Switzerland; 5University of Lausanne, University of Geneva,
Lausanne, Geneva, Switzerland
We characterized for the first time the in vivo and longitudinal progression of HE in a model of CLD using 1H MRS and histology and consequently we were able to monitor changes in the brain osmolytes, neurotransmitters, antioxidants and cell swelling.