Martin Wilson1,
2, Theodoros N. Arvanitis, 23, Andrew C. Peet1,
2
1School
of Cancer Sciences, Birmingham, West Midlands, United Kingdom; 2Birmingham
Children's Hospital, Birmingham, West Midlands, United Kingdom; 3School
of Electronic, Electrical & Computer Engineering, University of
Birmingham, Birmingham, West Midlands, United Kingdom
In this study the effects of chemical shift displacement (CSD) on simulated basis set analyses are demonstrated for short-echo 3T MRS data collected from phantoms and patients. An improvement in fit quality was observed on metabolite phantom data when CSD effects are modelled in basis set simulation. A bias in lactate and lipid measurements was also apparent in brain tumour MRS data when CSD effects are omitted. In conclusion, CSD modelling is an important consideration for the measurement of coupled metabolites at 3T using simulated basis sets.