Stefan Posse1,
2, Elena Ackley1, Jingjing Michele Zhang3,
Tongsheng Zhang1
1Neurology,
University of New Mexico, Albuquerque, NM, United States; 2Electrical
and Computer Engineering, University of New Mexico, Albuquerque, NM, United
States; 3Department of Biomedical Physics, David Geffen School of
Medicine at UCLA, University of California, Los Angeles, CA, United States
Diffusion tensor spectroscopic imaging (DTSI) in human brain was developed using high-speed proton-echo-planar-spectroscopic-imaging (PEPSI) with ECG gating, correction of movement-related phase errors using spatially localized echo-planar navigator signal acquisition and compensation of the variability in T1-saturation, which results from cardiac gating. DTSI was implemented on a 3 Tesla clinical scanner equipped with a 32-channel array coil. Data in a phantom and in 3 healthy volunteers were acquired using a 32x32 spatial matrix, 1 cc voxel size, bmax = 1734 s/mm2, and 6 gradient directions. Apparent diffusion coefficients and fractional anisotropy values of Cho, Cr, NAA and tissue water measured in a supraventricular slice were in the ranges reported in previous studies using single voxel methods and using diffusion tensor MRI. 3D DTSI is currently under development.