Abstract #3918

Evaluation of Renal Metabolic Response to Partial Ureteral Obstruction with Hyperpolarized 13C MRI

David J. Niles¹, Jeremy W. Gordon², Gengwen Huang³, Kevin M. Johnson¹, Arjang Djamali⁴, Sean B. Fain¹,⁵

¹Medical Physics, University of Wisconsin, Madison, WI, United States; ²Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; ³Surgery, University of Wisconsin, Madison, WI, United States; ⁴Medicine, University of Wisconsin, Madison, WI, United States; ⁵Radiology, University of Wisconsin, Madison, WI, United States

Congenital obstructive nephropathy is the most common cause of end-stage renal disease in children, and there is a need to improve tools for early diagnosis. In this study we used hyperpolarized ¹³C MRI to longitudinally and non-invasively assess the hemodynamic and metabolic changes in the kidney following partial unilateral ureteral obstruction. We observed reduced blood flow to the obstructed kidney and a preferential shift toward glycolysis in both kidneys. Our results may contribute to the understanding of the pathogenesis of obstructive nephropathy and to the development of improved approaches for clinical assessment.