Imramsjah M.J. van der Bom1,
Matthew J. Gounis1, Shaokuan Zheng2, Juyu Chueh1,
Anna Luisa Khn1, Alexei A. Bogdanov3
1Radiology/NECStR,
University of Massachusetts Medical School, Worcester, MA, United States; 2Radiology/AMRIC,
University of Massachusetts Medical School, Worcester, MA, United States; 3Radiology/Nuclear
Medicine, University of Massachusetts Medical School, Worcester, MA, United
States
To investigate the role of unruptured aneurysm wall inflammation and propensity for rupture, imaging parameters of a motion-sensitized driven-equilibrium black-blood sequence were optimized to suppress signal caused by slow non-linear blood flow within aneurysms while preserving CNR from surrounding tissue. Parameter optimization was performed using a silicone vascular replica and a rabbit aneurysm model. The optimized sequence was used to investigate signal enhancement of inflamed aneurysm walls in rabbits using a MPO-specific contrast agent. Blood signal within the aneurysms was sufficiently suppressed in all rabbits and a significant increase of SNR was observed in the inflamed aneurysms compared to controls.