Experimental and Simulation Studies on the Behavior of Signal Harmonics in Magnetic Particle Imaging

Kenya Murase¹, Takashi Konishi¹, Yuki Takeuchi¹, Ruiciao Song¹, Hiroya Suzuki¹, Hiroshige Takata¹, Shigeyoshi Saito¹

Recently, a new imaging method called magnetic particle imaging (MPI) has been introduced that allows for imaging the spatial distribution of magnetic nanoparticles (MNPs) with high sensitivity and spatial resolution. In this study, we investigated the behavior of signal harmonics in MPI under various conditions of drive and selection magnetic fields by experimental and simulation studies. We also investigated the dependency of signal harmonics on the particle size of MNPs by simulation studies based on the particle sizes actually measured. This study will be useful for better understanding, optimization, and development of MPI and for designing MNPs appropriate for MPI.