Abstract #3198

How Is the Fractional Anisotropy Affected by Frequency-Dependent Changes to the Eigenvalues of the Apparent Diffusion Tensor Measured with Oscillating-Gradient Spin-Echo Diffusion Tensor Imaging?

Jeff Kershaw¹,², Christoph Leuze³, Ichio Aoki¹, Takayuki Obata⁴, Iwao Kanno¹, Hiroshi Ito¹, Yuki Yamaguchi², Hiroshi Handa²

¹Molecular Imaging Centre, National Institute of Radiological Sciences, Chiba, Japan; ²School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan; ³Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; ⁴Research Centre for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan

Recent work applying the oscillating-gradient spin-echo sequence to diffusion-tensor imaging of in vivo rat brain has found substantial, approximately linear changes with frequency to the eigenvalues (EVs) of the apparent diffusion tensor and to the fractional isotropy (FA). While the FA is a well known function of the EVs, it is not immediately clear how the behaviour of the EVs relates to the trends in the FA. This work investigates how the FA is affected by changes to the EVs.