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Abstract #3118

Validation of Cerebral Blood Volume Quantification in Humans by Rapid Steady State T1 MRI

Teodora-Adriana Perles-Barbacaru1, Irne Troprs2, David Chechin3, Sylvie Grand2, Jean-Franois Le Bas2, Francois Berger2, Hana Lahrech2

1Grenoble Institute of Neurosciences, University of Joseph Fourier, INSERM U 836 , La Tronche, France; 2Grenoble Institute of Neurosciences, University of Joseph Fourier, INSERM U 836, La Tronche, France; 3Philips Healthcare, Suresnes, France


The Rapid Steady State T1 technique enables direct quantitative mapping of the cerebral blood volume fraction with a clinically approved Gd-DOTA dose during the first pass and without requirement of the arterial input function. It facilitates treatment monitoring and clinical studies in particular for the evaluation of antiangiogenic therapies.