Abstract #3117

Measurement of Portal Venous Flow Using Phase-Contrast MRI at 9.4T: Preliminary Repeatability, Reproducibility and Invasive Validation Studies

Manil Chouhan¹,², Alan Bainbridge³, Nathan Davies⁴, Rajiv Jalan⁴, Rajeshwar Mookerjee⁴, Simon Walker-Samuel², Mark F. Lythgoe², Shonit Punwani¹, Stuart Taylor¹

¹UCL Centre for Medical Imaging, University College London, London, United Kingdom; ²UCL Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom; ³Department of Medical Physics, University College Hospitals NHS Trust, London, United Kingdom; ⁴UCL Institute for Liver and Digestive Health, University College London, London, United Kingdom

The lack of robust non-invasive techniques for repeated measurement of liver blood flow has restricted understanding of the vascular changes underpinning chronic liver disease and the development of therapies to address these changes. Phase-contrast MRI has potential for portal venous flow quantification and in this study we demonstrate repeatability of phase-contrast MRI and present encouraging initial data demonstrating reproducibility of measurements and validation of flow quantification against invasive transit-time ultrasound measurements.