Wilson B. Chwang1,
Rajan Jain1, 2, Siamak P. Nejad-Davarani3,
4, A.S.M. Iskander1, Ashley VanSlooten5, Lonni
Schultz5, James R. Ewing3, 6, Ali S. Arbab1,
7, Hassan Bagher-Ebadian3, 6
1Department
of Radiology, Henry Ford Hospital, Detroit, MI, United States; 2Department
of Neurosurgery, Henry Ford Hospital, Detroit, MI, United States; 3Department
of Neurology, Henry Ford Hospital, Detroit, MI, United States; 4Department
of Biomedical Engineering, University of Michigan, Ann Artbor, MI, United
States; 5Department of Public Health Sciences, Henry Ford
Hospital, Detroit, MI, United States; 6Department of Physics,
Oakland University, Rochester Hills, MI, United States; 7Department
of Radiology, Wayne State University, Detroit, MI, United States
The purpose of this study was to investigate parameters of vascular physiology such as vp, Ktrans, and ve in a rat glioma model using two different contrast agents, an intravascular or blood pool agent (gadofosveset) and an extravascular agent (gadopentetate dimeglumine, Gd-DTPA) using DCE T1 nested model selection. We found that Ktrans was significantly lower using gadofosveset compared to Gd-DTPA, while vp and ve measures were not statistically different. But more importantly these parameters were measured with high agreement using DCE T1 NMS, demonstrating the stability of nested model selection in DCE-MRI and its importance for assessing the tumor microenvironment.