Abstract #3046

Correlation Between Cerebral Blood Flow and Anisotropy in White Matter

Andrea Federspiel¹, Sebastian Walther¹, Ariane Orosz¹, Roland Wiest², Stphanie Giezendanner¹, Jennifer Andreotti¹, Simon Schwab¹, Thomas Dierks¹, Kay Jann¹

¹Dept. of Psychiatric Neurophysiology, University Hospital of Psychiatry / University of Bern, Bern, Switzerland; ²Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland

In the present study the relationship between cerebral blood flow (CBF) and fractional anisotropy (FA) within white matter was investigated in a cohort of twenty four healthy subjects. After rigorous treatment of partial volume effects a significant negative linear relationship located within the splenium of the corpus callosum was observed between these variables in all subjects. The findings of the present study are in line with previous findings, but with a larger sample. The inverse relationship could indicate a dependency of CBF values with averaged axonal diameter of the tracts within WM.