1Center
for MR Research, University of Illinois Hospital & Health Sciences
System, Chicago, IL, United States; 2Department of Bioengineering,
University of Illinois at Chicago, Chicago, IL, United States; 3Applied
Science Lab, GE Healthcare, Shanghai, China; 4Department of
Radiology, University of Illinois Hospital & Health Sciences System,
Chicago, IL, United States; 5Department of Radiology, Xinhua
Hospital, Shanghai, China; 6Departments of Radiology, Neurosurgery
and Bioengineering, University of Illinois Hospital & Health Sciences
System, Chicago, IL, United States
A systematic comparison of non-Gaussian diffusion models is conducted in the context of differentiating pediatric brain tumors. Three non-Gaussian diffusion models - FROC, kurtosis and bi-exponential models - were selected for evaluation of their performance for differentiating low-grade from high-grade pediatric brain tumors. Our results suggested that FROC model had the best performance, although the other two models also produced excellent results. In conclusion, non-Gaussian diffusion models with high b-values (up to 4000 s/mm2) can provide valuable and reliable information for characterizing pediatric brain tumors.