Abstract #2889

Iron-Related Microstructural Alterations in Deep Gray Matter: Correlations from Diffusional Kurtosis Imaging and Quantitative Susceptibility Mapping

Nan-Jie Gong¹, Chun-Sing Wong¹, Chun-Chung Chan², Lam-Ming Leung², Queenie Chan³

¹Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; ²United Christian Hospital, Hong Kong, China; ³Philips Healthcare, Hong Kong, China

Using both quantitative susceptibility mapping (QSM) and diffusional kurtosis imaging (DKI) methods, we investigated age-related iron depositions in subcortical gray matters of globus pallidus (GP) and putamen (Pu). Besides, the contribution of iron deposition with aging to microstructural alterations in deep gray matter has also been studied by testing correlations between DKI parameters and susceptibility.