Abstract #2887

Neural Correlates of Constructional Apraxia in Patients with Alzheimers Disease.

Laura Serra¹, Lucia Fadda², Roberta Perri², Barbara Span¹, Mario Torso¹, Diana Castelli³, Camillo Marra³, Carlo Caltagirone², Marco Bozzali⁴

¹Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; ²Neurological and behavioural laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; ³Institute of Neurology, Universit Cattolica, Roma, Italy; ⁴Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy

Using voxel-based morphometry we investigated the pathophysioological substrate of constructive apraxia (CA) in patients Alzheimer's disease (AD). A peculiar pattern of regional GM atrophy was present in those patients with CA manifestations but not in the others. Our findings fit well with current anatomo-functional theories on CA.