Ming-Ching Chang1,
Sandeep Narendra Gupta1, Laura I. Sacolick2, Clare
Tempany-Afdhal3, Fiona Fennessy3, Ehud J. Schmidt3
1GE
Global Research Center, Niskayuna, NY, United States; 2GE Global
Research Center, Munich, Germany; 3Radiology, Brigham and Women's
Hospital, Boston, MA, United States
Dynamic Contrast Enhanced MRI (DCE-MRI) is used for the assessment of tumor vascular properties with application to prostate cancer staging and treatment monitoring. Analysis of DCE-MRI requires knowledge of pre-contrast T1 maps. T1 mapping using Variable Flip Angle imaging is inaccurate due to B1 inhomogeneity. We present improved T1 mapping and PK quantification in prostate DCE-MRI at 3T by incorporating B1 inhomogeneity correction using the Bloch-Siegert B1 mapping method. We validated the method on 26 subjects and demonstrated good T1 quantification and better PK maps by incorporating B1 correction into DCE-MRI quantification.