Erin K. Englund1,
Michael C. Langham1, Cheng Li1, Emile R. Mohler2,
Thomas F. Floyd3, Felix W. Wehrli1
1Department
of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Department
of Cardiology, University of Pennsylvania, Philadelphia, PA, United States; 3Department
of Anesthesiology, Stony Brook University, Stony Brook, NY, United States
A novel method to simultaneously measure perfusion, venous oxygen saturation, and skeletal muscle T2* using an interleaved pulsed arterial spin labeling and multi-echo GRE sequence, termed PASL/Ox-BOLD, is presented. The technique is assessed in healthy subjects during a series of ischemia reperfusion paradigms. Time course data is analyzed to investigate the kinetics of recovery following cuff-induced ischemia. Results indicate that PASL/Ox-BOLD is capable of faithfully measuring all three parameters at 2 second temporal resolution. The method is also used to investigate a small cohort of peripheral artery disease patients. In these patients, a blunted and delayed hyperemic response is detected.